About the structure and biological function of oxiChol
Structure. Oxidized cholesterols (cholesterol oxides, or oxiChol) belong to the group of cholesterol lipids within the sterol lipids category. Their structure consists of cholesterol: four linked hydrocarbon rings to which a hydrocarbon tail and a hydroxy group are linked. Oxidized cholesterols further encompass oxygen containing substituents such as hydroxyl and epoxy groups.
Function. Oxidized cholesterols act as potent inhibitors of cholesterol biosynthesis through inhibiting the enzyme HMG-CoA reductase. The formation of oxiChols is an indicator of lipid peroxidation, connecting oxidative stress to atherosclerosis, as oxidized cholesterols contribute to plaque formation. Further, oxidized cholesterols are involved in the pathogenesis and progression of other diseases, including neurodegenerative disorders, and age-related conditions, and may serve as biomarkers in conditions like Niemann-Pick C1 disease.
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
★★★★★
Thank you once again. The timing is extremely helpful to us.
Susan Macdonald
Aldeyra Therapeutics
Thank you very much. The results look fantastic!
Stan Neufeld
Friedrich Miescher Institute
The high-speed turn around when under revision really helped us!
Rose E Goodchild
KU Leuven
We highly appreciate the personal support and consultation.
Rainer Voegeli
DSM Skin Biology
We have been quite impressed. The results clearly indicate a difference.
Pietro De Camilli
Yale University
Cooperating with Lipotype, I enjoy custom packages and great support!
Olga Ramich
DIfE
After moving from one continent to another, I still prefer Lipotype!
Julie Jacquemyn
University of Alberta
Thank you very much for my new and shiny lipidomics data set!
Ilya Levental
University of Virginia
Lipotype Lipidomics is instrumental to our studies of membranes.
Christopher J Stefan
University College London
Lipotype is truly dedicated to supporting scientists in their research.
Anonymous
Anonymous
Request Analysis
You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!
You are currently viewing a placeholder content from OpenStreetMap. To access the actual content, click the button below. Please note that doing so will share data with third-party providers.
